Tag: dh5a

Gene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GISTGene duplication, rather than epigenetic changes, drives FGF4 overexpression in KIT/PDGFRA/SDH/RAS-P WT GIST

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Gastrointestinal stromal tumours which are wild sort for KIT and PDGFRA are known as WT GISTs. Of those tumours, SDH-deficient (characterised by the lack of SDHB) and quadruple WT GIST