Purification of the individual snRNPs U1, U2, U5 and U4/U6 from HeLa cells and characterization of their protein constituents.

A process is described for the purification of the person main small nuclear ribonucleoproteins (snRNPs) U1, U2, U5 and U4/U6 from HeLa cells. The salient characteristic of the

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Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies.

The MTS1/CDKN2/p16 gene encoding the p16INK4a tumor-suppressor protein is usually inactivated by homozygous deletion or hypermethylation of the promoter in a variety of human malignancies.

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